CD169-Mediated Trafficking of HIV to Plasma Membrane Invaginations in Dendritic Cells Attenuates Efficacy of Anti-gp120 Broadly Neutralizing Antibodies

Myeloid dendritic cells (DCs) can capture HIV-1 via the receptor CD169/Siglec-1 that binds to the ganglioside, GM3, in the virus particle membrane. In turn, HIV-1 particles captured by CD169, an I-type lectin, whose expression on DCs is enhanced upon maturation with LPS, are protected from degradati...

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Udgivet i:PLoS Pathog
Main Authors: Akiyama, Hisashi, Ramirez, Nora-Guadalupe Pina, Gudheti, Manasa V., Gummuluru, Suryaram
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356592/
https://ncbi.nlm.nih.gov/pubmed/25760631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004751
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