Vitamin B(12) insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes

BACKGROUND: The dietary supply of methyl donors such as folate, vitamin B(12), betaine, methionine, and choline is essential for normal growth, development, and physiological functions through the life course. Both human and animal studies have shown that vitamin B(12) deficiency is associated with...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Principais autores: Adaikalakoteswari, Antonysunil, Finer, Sarah, Voyias, Philip D, McCarthy, Ciara M, Vatish, Manu, Moore, Jonathan, Smart-Halajko, Melissa, Bawazeer, Nahla, Al-Daghri, Nasser M, McTernan, Philip G, Kumar, Sudhesh, Hitman, Graham A, Saravanan, Ponnusamy, Tripathi, Gyanendra
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356060/
https://ncbi.nlm.nih.gov/pubmed/25763114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0046-8
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