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LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor
Sequential proteolytic cleavages of amyloid-β protein precursor (AβPP) by β-secretase and γ-secretase generate amyloid β (Aβ) peptides, which are thought to contribute to Alzheimer's disease (AD). Much of this processing occurs in endosomes following endocytosis of AβPP from the plasma membrane...
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| Publicado no: | Pathobiol Aging Age Relat Dis |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Co-Action Publishing
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4355507/ https://ncbi.nlm.nih.gov/pubmed/25758563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3402/pba.v5.25796 |
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