A Tail of Two Sites: A Bipartite Mechanism for Recognition of Notch Ligands by Mind Bomb E3 Ligases

Mind bomb (Mib) proteins are large, multi-domain E3 ligases that promote ubiquitination of the cytoplasmic tails of Notch ligands. This ubiquitination step marks the ligand proteins for epsin-dependent endocytosis, which is critical for in vivo Notch receptor activation. We present here crystal stru...

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Vydáno v:Mol Cell
Hlavní autoři: McMillan, Brian J., Schnute, Björn, Ohlenhard, Nadja, Zimmerman, Brandon, Miles, Laura, Beglova, Natalia, Klein, Thomas, Blacklow, Stephen C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355479/
https://ncbi.nlm.nih.gov/pubmed/25747658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.019
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