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Application of Caco-2 Cell Line in Herb-Drug Interaction Studies: Current Approaches and Challenges
The Caco-2 model is employed in pre-clinical investigations to predict the likely gastrointestinal permeability of drugs because it expresses cytochrome P450 enzymes, transporters, microvilli and enterocytes of identical characteristics to the human small intestine. The FDA recommends this model as...
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| Publicado no: | J Pharm Pharm Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4355448/ https://ncbi.nlm.nih.gov/pubmed/24735758 |
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