Protease 3C of hepatitis A virus induces vacuolization of lysosomal/endosomal organelles and caspase-independent cell death

BACKGROUND: 3C proteases, the main proteases of picornaviruses, play the key role in viral life cycle by processing polyproteins. In addition, 3C proteases digest certain host cell proteins to suppress antiviral defense, transcription, and translation. The activity of 3C proteases per se induces hos...

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Detalhes bibliográficos
Publicado no:BMC Cell Biol
Main Authors: Shubin, Andrey V, Demidyuk, Ilya V, Lunina, Nataliya A, Komissarov, Alexey A, Roschina, Marina P, Leonova, Olga G, Kostrov, Sergey V
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355371/
https://ncbi.nlm.nih.gov/pubmed/25886889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-015-0050-z
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