De novo pulmonary small cell carcinomas and large cell neuroendocrine carcinomas harboring EGFR mutations: lack of response to EGFR inhibitors

INTRODUCTION: Epidermal growth factor receptor (EGFR) mutations are present in 10-20% of all non-small-cell lung cancers and predict for response to EGFR tyrosine kinase inhibitors (TKIs). However, the incidence of these mutations and their ability to predict response to TKIs in high-grade pulmonary...

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Détails bibliographiques
Publié dans:Lung Cancer
Auteurs principaux: Le, Xiuning, Desai, Neelam V., Majid, Adnan, Karp, Rebecca S., Huberman, Mark S., Rangachari, Deepa, Kent, Michael S., Gangadharan, Sidharta P., Folch, Erik, VanderLaan, Paul A., Costa, Daniel B.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355318/
https://ncbi.nlm.nih.gov/pubmed/25700797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2015.02.003
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