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Dosage Compensation in Mammals

Many organisms show major chromosomal differences between sexes. In mammals, females have two copies of a large, gene-rich chromosome, the X, whereas males have one X and a small, gene-poor Y. The imbalance in expression of several hundred genes is lethal if not dealt with by dosage compensation. Th...

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Publié dans:Cold Spring Harb Perspect Biol
Auteurs principaux: Brockdorff, Neil, Turner, Bryan M.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355265/
https://ncbi.nlm.nih.gov/pubmed/25731764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a019406
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