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Structural basis for the activation and inhibition of the UCH37 deubiquitylase
The UCH37 deubiquitylase functions in two large and very different complexes, the 26S proteasome and the INO80 chromatin remodeler. We have performed biochemical characterization and determined crystal structures of UCH37 in complexes with RPN13 and NFRKB, which mediate its recruitment to proteasome...
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| Publicado no: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4355076/ https://ncbi.nlm.nih.gov/pubmed/25702872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.016 |
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