Genome-Wide Meta-Analyses of Plasma Renin Activity and Concentration Reveal Association with the Kininogen 1 and Prekallikrein Genes

BACKGROUND: The renin-angiotensin-aldosterone-system (RAAS) is critical for regulation of blood pressure and fluid balance and influences cardiovascular remodeling. Dysregulation of the RAAS contributes to cardiovascular and renal morbidity. The genetic architecture of circulating RAAS components is...

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Publicado no:Circ Cardiovasc Genet
Main Authors: Lieb, Wolfgang, Chen, Ming-Huei, Teumer, Alexander, de Boer, Rudolf A., Lin, Honghuang, Fox, Ervin R., Musani, Solomon K., Wilson, James G., Wang, Thomas J., Völzke, Henry, Petersen, Ann-Kristin, Meisinger, Christine, Nauck, Matthias, Schlesinger, Sabrina, Li, Yong, Menard, Jöel, Hercberg, Serge, Wichmann, H.-Erich, Völker, Uwe, Rawal, Rajesh, Bidlingmaier, Martin, Hannemann, Anke, Dörr, Marcus, Rettig, Rainer, van Gilst, Wiek H., van Veldhuisen, Dirk J., Bakker, Stephan J.L., Navis, Gerjan, Wallaschofski, Henri, Meneton, Pierre, van der Harst, Pim, Reincke, Martin, Vasan, Ramachandran S., Consortium, CKDGen
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354880/
https://ncbi.nlm.nih.gov/pubmed/25477429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.114.000613
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