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Process development for the production of 15β-hydroxycyproterone acetate using Bacillus megaterium expressing CYP106A2 as whole-cell biocatalyst
BACKGROUND: CYP106A2 from Bacillus megaterium ATCC 13368 was first identified as a regio- and stereoselective 15β-hydroxylase of 3-oxo-∆(4)-steroids. Recently, it was shown that besides 3-oxo-∆(4)-steroids, 3-hydroxy-∆(5)-steroids as well as di- and triterpenes can also serve as substrates for this...
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| Publicado no: | Microb Cell Fact |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4354754/ https://ncbi.nlm.nih.gov/pubmed/25890176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-015-0210-z |
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