Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells

Gastric cancer is the second leading cause of cancer-related death worldwide, with a poor response to current chemotherapy. Danusertib is a pan-inhibitor of the Aurora kinases and a third-generation Bcr-Abl tyrosine kinase inhibitor with potent anticancer effects, but its antitumor effect and underl...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Drug Des Devel Ther
Autori principali: Yuan, Chun-Xiu, Zhou, Zhi-Wei, Yang, Yin-Xue, He, Zhi-Xu, Zhang, Xueji, Wang, Dong, Yang, Tianxing, Pan, Si-Yuan, Chen, Xiao-Wu, Zhou, Shu-Feng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2015
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354435/
https://ncbi.nlm.nih.gov/pubmed/25767376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S74964
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