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Shikonin Isolated from Lithospermum erythrorhizon Downregulates Proinflammatory Mediators in Lipopolysaccharide-Stimulated BV2 Microglial Cells by Suppressing Crosstalk between Reactive Oxygen Species and NF-κB

According to the expansion of lifespan, neuronal disorder based on inflammation has been social problem. Therefore, we isolated shikonin from Lithospermum erythrorhizon and evaluated anti-inflammatory effects of shikonin in lipopolysaccharide (LSP)-stimulated BV2 microglial cells. Shikonin dose-depe...

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Detalhes bibliográficos
Publicado no:Biomol Ther (Seoul)
Main Authors: Prasad, Rajapaksha Gedara, Choi, Yung Hyun, Kim, Gi-Young
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Society of Applied Pharmacology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354311/
https://ncbi.nlm.nih.gov/pubmed/25767678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2015.006
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