Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling

Akt2 and its downstream effectors mediate insulin-stimulated GLUT4-storage vesicle (GSV) translocation and fusion with the plasma membrane (PM). Using mass spectrometry, we identify actin-capping protein Tropomodulin 3 (Tmod3) as an Akt2-interacting partner in 3T3-L1 adipocytes. We demonstrate that...

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發表在:Nat Commun
Main Authors: Lim, Chun-Yan, Bi, Xuezhi, Wu, Donghai, Kim, Jae Bum, Gunning, Peter W., Hong, Wanjin, Han, Weiping
格式: Artigo
語言:Inglês
出版: Nature Pub. Group 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354152/
https://ncbi.nlm.nih.gov/pubmed/25575350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6951
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