p53 Suppresses Tetraploid Development in Mice

Mammalian tetraploid embryos die in early development because of defects in the epiblast. Experiments with diploid/tetraploid chimeric mice, obtained via the aggregation of embryonic stem cells, clarified that while tetraploid cells are excluded from epiblast derivatives, diploid embryos with tetrap...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Horii, Takuro, Yamamoto, Masamichi, Morita, Sumiyo, Kimura, Mika, Nagao, Yasumitsu, Hatada, Izuho
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354145/
https://ncbi.nlm.nih.gov/pubmed/25752699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08907
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