Efficient Differentiation of Steroidogenic and Germ-Like Cells from Epigenetically-Related iPSCs Derived from Ovarian Granulosa Cells

To explore restoration of ovarian function using epigenetically-related, induced pluripotent stem cells (iPSCs), we functionally evaluated the epigenetic memory of novel iPSC lines, derived from mouse and human ovarian granulosa cells (GCs) using c-Myc, Klf4, Sox2 and Oct4 retroviral vectors. The st...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Anchan, Raymond, Gerami-Naini, Behzad, Lindsey, Jennifer S., Ho, Joshua W. K., Kiezun, Adam, Lipskind, Shane, Ng, Nicholas, LiCausi, Joseph A., Kim, Chloe S., Brezina, Paul, Tuschl, Thomas, Maas, Richard, Kearns, William G., Williams, Zev
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353623/
https://ncbi.nlm.nih.gov/pubmed/25751620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119275
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