P38/MAPK contributes to endothelial barrier dysfunction via MAP4 phosphorylation-dependent microtubule disassembly in inflammation-induced acute lung injury

Excessive activation of inflammation and the accompanying lung vascular endothelial barrier disruption are primary pathogenic features of acute lung injury (ALI). Microtubule-associated protein 4 (MAP4), a tubulin assembly-promoting protein, is important for maintaining the microtubule (MT) cytoskel...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Li, Lingfei, Hu, Jiongyu, He, Ting, Zhang, Qiong, Yang, Xu, Lan, Xiaodong, Zhang, Dongxia, Mei, Hao, Chen, Bing, Huang, Yuesheng
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352893/
https://ncbi.nlm.nih.gov/pubmed/25746230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08895
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