Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance

Cell stress is implicated in triggering bouts of systemic inflammation in patients with autoinflammatory disorders. Blood monocytes from patients affected by NLRP3-mediated cryopyrin-associated periodic syndromes (CAPS) release greater amounts of IL-1β than monocytes from unaffected subjects. Here w...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Carta, Sonia, Penco, Federica, Lavieri, Rosa, Martini, Alberto, Dinarello, Charles Anthony, Gattorno, Marco, Rubartelli, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352822/
https://ncbi.nlm.nih.gov/pubmed/25730877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424741112
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