Predicting functional and regulatory divergence of a drug resistance transporter gene in the human malaria parasite

BACKGROUND: The paradigm of resistance evolution to chemotherapeutic agents is that a key coding mutation in a specific gene drives resistance to a particular drug. In the case of resistance to the anti-malarial drug chloroquine (CQ), a specific mutation in the transporter pfcrt is associated with r...

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Bibliographic Details
Published in:BMC Genomics
Main Authors: Siwo, Geoffrey H, Tan, Asako, Button-Simons, Katrina A, Samarakoon, Upeka, Checkley, Lisa A, Pinapati, Richard S, Ferdig, Michael T
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352545/
https://ncbi.nlm.nih.gov/pubmed/25765049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-015-1261-6
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