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A Conserved Domain in the Scc3 Subunit of Cohesin Mediates the Interaction with Both Mcd1 and the Cohesin Loader Complex

The Structural Maintenance of Chromosome (SMC) complex, termed cohesin, is essential for sister chromatid cohesion. Cohesin is also important for chromosome condensation, DNA repair, and gene expression. Cohesin is comprised of Scc3, Mcd1, Smc1, and Smc3. Scc3 also binds Pds5 and Wpl1, cohesin-assoc...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Orgil, Ola, Matityahu, Avi, Eng, Thomas, Guacci, Vincent, Koshland, Douglas, Onn, Itay
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352044/
https://ncbi.nlm.nih.gov/pubmed/25748820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005036
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