Deconvoluting the Composition of Low-Frequency Hepatitis C Viral Quasispecies: Comparison of Genotypes and NS3 Resistance-Associated Variants between HCV/HIV Coinfected Hemophiliacs and HCV Monoinfected Patients in Japan

Pre-existing low-frequency resistance-associated variants (RAVs) may jeopardize successful sustained virological responses (SVR) to HCV treatment with direct-acting antivirals (DAAs). However, the potential impact of low-frequency (∼0.1%) mutations, concatenated mutations (haplotypes), and their ass...

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Udgivet i:PLoS One
Main Authors: Ogishi, Masato, Yotsuyanagi, Hiroshi, Tsutsumi, Takeya, Gatanaga, Hiroyuki, Ode, Hirotaka, Sugiura, Wataru, Moriya, Kyoji, Oka, Shinichi, Kimura, Satoshi, Koike, Kazuhiko
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351984/
https://ncbi.nlm.nih.gov/pubmed/25748426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119145
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