Transport domain unlocking sets the uptake rate of an aspartate transporter

Glutamate transporters terminate neurotransmission by clearing synaptically released glutamate from the extracellular space, allowing repeated rounds of signaling and preventing glutamate-mediated excitotoxicity. Crystallographic studies on an archaeal homologue, Glt(Ph), showed that distinct transp...

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Bibliographic Details
Published in:Nature
Main Authors: Akyuz, Nurunisa, Georgieva, Elka R., Zhou, Zhou, Stolzenberg, Sebastian, Cuendet, Michel A., Khelashvili, George, Altman, Roger B., Terry, Daniel S., Freed, Jack H., Weinstein, Harel, Boudker, Olga, Blanchard, Scott C.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351760/
https://ncbi.nlm.nih.gov/pubmed/25652997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14158
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