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Oxidative Stress Activates Endothelial Innate Immunity via Sterol Regulatory Element Binding Protein 2 (SREBP2) Transactivation of MiRNA-92a

BACKGROUND: Oxidative stress activates endothelial innate immunity and disrupts endothelial functions, including eNOS-derived NO bioavailability. Here, we postulated that oxidative stress induces sterol regulatory element binding protein 2 (SREBP2) and microRNA-92a (miR-92a), which in turn activate...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Chen, Zhen, Wen, Liang, Martin, Marcy, Hsu, Chien-Yi, Fang, Longhou, Lin, Feng-Mao, Lin, Ting-Yang, Geary, McKenna J., Geary, Gregory, Zhao, Yongli, Johnson, David A., Chen, Jaw-Wen, Lin, Shing-Jong, Chien, Shu, Huang, Hsien-Da, Miller, Yury I., Huang, Po-Hsun, Shyy, John Y-J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351177/
https://ncbi.nlm.nih.gov/pubmed/25550450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.114.013675
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