Overexpression of cystatin C in synovium does not reduce synovitis or cartilage degradation in established osteoarthritis

INTRODUCTION: Cathepsin K (catK) expression is increased in cartilage, bone and synovium during osteoarthritis (OA). To study the role of catK expression and elevated cathepsin activity in the synovium on cartilage destruction in established OA, we overexpressed cystatin C (cysC), a natural cysteine...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Kyostio-Moore, Sirkka, Piraino, Susan, Berthelette, Patricia, Moran, Nance, Serriello, Joseph, Bendele, Alison, Sookdeo, Cathleen, Nambiar, Bindu, Ewing, Patty, Armentano, Donna, Matthews, Gloria L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350912/
https://ncbi.nlm.nih.gov/pubmed/25592743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0519-3
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