Crystal structure of (S)-2-[(3S,8S,9S,10R,13S,14S,17R)-3-hy­droxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetra­deca­hydro-1H-cyclo­penta[a]phenanthren-17-yl]-N-meth­oxy-N-methyl­pro­pan­amide (Fernholz Weinreb amide)

The literature compound 3β-hy­droxy-bis­nor-5-cholenic aldehyde is an important inter­mediate for the synthesis of new modulators of the nuclear oxysterol receptor Liver X. As part of our ongoing search for new LXR antagonists, the title compound, C(24)H(39)NO(3), has proven to be an important inter...

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Библиографические подробности
Опубликовано в: :Acta Crystallogr E Crystallogr Commun
Главные авторы: Viktorsson, Elvar Ørn, Åstrand, Ove Alexander Høgmoen, Haseeb, Rasha Sabah, Görbitz, Carl Henrik, Rongved, Pål
Формат: Artigo
Язык:Inglês
Опубликовано: International Union of Crystallography 2015
Предметы:
Research Communications
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350737/
https://ncbi.nlm.nih.gov/pubmed/25844186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2056989015001747
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