Crystal structure of (S)-2-[(3S,8S,9S,10R,13S,14S,17R)-3-hy­droxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetra­deca­hydro-1H-cyclo­penta[a]phenanthren-17-yl]-N-meth­oxy-N-methyl­pro­pan­amide (Fernholz Weinreb amide)

The literature compound 3β-hy­droxy-bis­nor-5-cholenic aldehyde is an important inter­mediate for the synthesis of new modulators of the nuclear oxysterol receptor Liver X. As part of our ongoing search for new LXR antagonists, the title compound, C(24)H(39)NO(3), has proven to be an important inter...

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Bibliografski detalji
Izdano u:Acta Crystallogr E Crystallogr Commun
Glavni autori: Viktorsson, Elvar Ørn, Åstrand, Ove Alexander Høgmoen, Haseeb, Rasha Sabah, Görbitz, Carl Henrik, Rongved, Pål
Format: Artigo
Jezik:Inglês
Izdano: International Union of Crystallography 2015
Teme:
Research Communications
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350737/
https://ncbi.nlm.nih.gov/pubmed/25844186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2056989015001747
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