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Spectrin binding motifs regulate Scribble cortical dynamics and polarity function
The tumor suppressor protein Scribble (SCRIB) plays an evolutionary conserved role in cell polarity. Despite being central for its function, the molecular basis of SCRIB recruitment and stabilization at the cell cortex is poorly understood. Here we show that SCRIB binds directly to the CH1 domain of...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4350421/ https://ncbi.nlm.nih.gov/pubmed/25664942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04726 |
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