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Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status

The presence of cancer stem cells (CSCs) is linked to preexisting or acquired drug resistance and tumor relapse. Therefore, targeting both differentiated tumor cells and CSCs was suggested as an effective approach for non-small cell lung cancer (NSCLC) treatment. After screening of chemotherapeutic...

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Publicat a:Oncotarget
Autors principals: Xiao, Zhiguang, Sperl, Bianca, Ullrich, Axel, Knyazev, Pjotr
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350329/
https://ncbi.nlm.nih.gov/pubmed/25375092
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