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Substitution of tryptophan 89 with tyrosine switches the DNA binding mode of PC4
PC4, a well-known general transcription cofactor, has multiple functions in transcription and DNA repair. Residue W89, is engaged in stacking interactions with DNA in PC4, but substituted by tyrosine in some PC4 orthologous proteins. In order to understand the consequences and reveal the molecular d...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4350104/ https://ncbi.nlm.nih.gov/pubmed/25739870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08789 |
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