Excess of Rare Variants in Genes that are Key Epigenetic Regulators of Spermatogenesis in the Patients with Non-Obstructive Azoospermia

Non-obstructive azoospermia (NOA), a severe form of male infertility, is often suspected to be linked to currently undefined genetic abnormalities. To explore the genetic basis of this condition, we successfully sequenced ~650 infertility-related genes in 757 NOA patients and 709 fertile males. We e...

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Udgivet i:Sci Rep
Main Authors: Li, Zesong, Huang, Yi, Li, Honggang, Hu, Jingchu, Liu, Xiao, Jiang, Tao, Sun, Guangqing, Tang, Aifa, Sun, Xiaojuan, Qian, Weiping, Zeng, Yong, Xie, Jun, Zhao, Wei, Xu, Yu, He, Tingting, Dong, Chengliang, Liu, Qunlong, Mou, Lisha, Lu, Jingxiao, Lin, Zheguang, Wu, Song, Gao, Shengjie, Guo, Guangwu, Feng, Qiang, Li, Yingrui, Zhang, Xiuqing, Wang, Jun, Yang, Huanming, Wang, Jian, Xiong, Chengliang, Cai, Zhiming, Gui, Yaoting
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350091/
https://ncbi.nlm.nih.gov/pubmed/25739334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08785
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