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Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-κB signaling pathway

AIM: Cathepsin L, a lysosomal cysteine proteinase, is exclusively elevated in a variety of malignancies, including gliomas. In this study we investigated the relationship between cathepsin L and NF-κB, two radiation-responsive elements, in regulating the sensitivity of human glioma cells ionizing ra...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Yang, Neng, Wang, Pan, Wang, Wen-juan, Song, Yun-zhen, Liang, Zhong-qin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349927/
https://ncbi.nlm.nih.gov/pubmed/25661319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.148
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