A Predictive In Vitro Model of the Impact of Drugs with Anticholinergic Properties on Human Neuronal and Astrocytic Systems

The link between off-target anticholinergic effects of medications and acute cognitive impairment in older adults requires urgent investigation. We aimed to determine whether a relevant in vitro model may aid the identification of anticholinergic responses to drugs and the prediction of anticholiner...

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Udgivet i:PLoS One
Main Authors: Woehrling, Elizabeth K., Parri, H. Rheinallt, Tse, Erin H. Y., Hill, Eric J., Maidment, Ian D., Fox, G. Christopher, Coleman, Michael D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349811/
https://ncbi.nlm.nih.gov/pubmed/25738989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118786
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