Loss of CITED1, an MITF regulator, drives a phenotype switch in vitro and can predict clinical outcome in primary melanoma tumours

CITED1 is a non-DNA binding transcriptional co-regulator whose expression can distinguish the ‘proliferative’ from ‘invasive’ signature in the phenotype-switching model of melanoma. We have found that, in addition to other ‘proliferative’ signature genes, CITED1 expression is repressed by TGFβ while...

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Detalhes bibliográficos
Publicado no:PeerJ
Main Authors: Howlin, Jillian, Cirenajwis, Helena, Lettiero, Barbara, Staaf, Johan, Lauss, Martin, Saal, Lao, Borg, Åke, Gruvberger-Saal, Sofia, Jönsson, Göran
Formato: Artigo
Idioma:Inglês
Publicado em: PeerJ Inc. 2015
Assuntos:
Bioinformatics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349148/
https://ncbi.nlm.nih.gov/pubmed/25755924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.788
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