Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis

Genome-wide association studies have identified a link between genetic variation at the human chromosomal locus 1p13.3 and coronary artery disease. The gene encoding sortilin (SORT1) has been implicated as the causative gene within the locus, as sortilin regulates hepatic lipoprotein metabolism. Her...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Mortensen, Martin B., Kjolby, Mads, Gunnersen, Stine, Larsen, Jakob V., Palmfeldt, Johan, Falk, Erling, Nykjaer, Anders, Bentzon, Jacob F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2014
Schlagworte:
Brief Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348947/
https://ncbi.nlm.nih.gov/pubmed/25401472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76002
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