Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

Innate immunity to viral infection involves induction of the type I IFN response; however, dysfunctional regulation of this pathway leads to inappropriate inflammation. Here, we evaluated a nonconsanguineous family of mixed European descent, with 4 members affected by systemic inflammatory and autoi...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Jeremiah, Nadia, Neven, Bénédicte, Gentili, Matteo, Callebaut, Isabelle, Maschalidi, Sophia, Stolzenberg, Marie-Claude, Goudin, Nicolas, Frémond, Marie-Louis, Nitschke, Patrick, Molina, Thierry J., Blanche, Stéphane, Picard, Capucine, Rice, Gillian I., Crow, Yanick J., Manel, Nicolas, Fischer, Alain, Bader-Meunier, Brigitte, Rieux-Laucat, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2014
Assuntos:
Brief Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348945/
https://ncbi.nlm.nih.gov/pubmed/25401470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79100
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