Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity

BACKGROUND: Inhalation of benzene at levels below the current exposure limit values leads to hematotoxicity in occupationally exposed workers. OBJECTIVE: We sought to evaluate Diversity Outbred (DO) mice as a tool for exposure threshold assessment and to identify genetic factors that influence benze...

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Udgivet i:Environ Health Perspect
Main Authors: French, John E., Gatti, Daniel M., Morgan, Daniel L., Kissling, Grace E., Shockley, Keith R., Knudsen, Gabriel A., Shepard, Kim G., Price, Herman C., King, Deborah, Witt, Kristine L., Pedersen, Lars C., Munger, Steven C., Svenson, Karen L., Churchill, Gary A.
Format: Artigo
Sprog:Inglês
Udgivet: NLM-Export 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348743/
https://ncbi.nlm.nih.gov/pubmed/25376053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1408202
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