Genome-Wide DNA Methylation Profiles Indicate CD8+ T Cell Hypermethylation in Multiple Sclerosis

OBJECTIVE: Determine whether MS-specific DNA methylation profiles can be identified in whole blood or purified immune cells from untreated MS patients. METHODS: Whole blood, CD4+ and CD8+ T cell DNA from 16 female, treatment naïve MS patients and 14 matched controls was profiled using the HumanMethy...

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Vydáno v:PLoS One
Hlavní autoři: Bos, Steffan D., Page, Christian M., Andreassen, Bettina K., Elboudwarej, Emon, Gustavsen, Marte W., Briggs, Farren, Quach, Hong, Leikfoss, Ingvild S., Bjølgerud, Anja, Berge, Tone, Harbo, Hanne F., Barcellos, Lisa F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348521/
https://ncbi.nlm.nih.gov/pubmed/25734800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117403
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