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Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B

Obstructive sleep apnea (OSA) is associated with cerebrovascular diseases. However, little is known regarding the effects of OSA on the cerebrovascular wall. We tested the hypothesis that OSA augments endothelin-1 (ET-1) constrictions of cerebral arteries. Repeated apneas (30 or 60 per hour) were pr...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Durgan, David J, Crossland, Randy F, Lloyd, Eric E, Phillips, Sharon C, Bryan, Robert M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348382/
https://ncbi.nlm.nih.gov/pubmed/25425077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.214
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