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Ube3a Imprinting Impairs Circadian Robustness in Angelman Syndrome Models
BACKGROUND: The paternal allele of Ube3a is silenced by imprinting in neurons, and Angelman Syndrome (AS) is a disorder arising from a deletion or mutation of the maternal Ube3a allele, which thereby eliminates Ube3a neuronal expression. Sleep disorders such as short sleep duration and increased sle...
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| Publicado no: | Curr Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4348236/ https://ncbi.nlm.nih.gov/pubmed/25660546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2014.12.047 |
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