Desensitization and immune tolerance induction in children with severe factor IX deficiency; inhibitors and adverse reactions to replacement therapy: a case-report and literature review

Hemophilia B is a rare X-linked recessive disorder with plasma factor IX (FIX) deficiency. 1-3% of patients treated with exogenous FIX-containing products develop inhibitors (i.e. polyclonal high affinity immunoglobulins) that neutralize the procoagulant activity of a specific coagulation factor. Al...

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Detalhes bibliográficos
Publicado no:Ital J Pediatr
Main Authors: Bon, Andrea, Morfini, Massimo, Dini, Alessandro, Mori, Francesca, Barni, Simona, Gianluca, Sottilotta, de Martino, Maurizio, Novembre, Elio
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347657/
https://ncbi.nlm.nih.gov/pubmed/25887512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13052-015-0116-8
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