The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive form of leukemia that is mainly diagnosed in children and shows a skewed gender distribution toward males. In this study, we report somatic loss-of-function mutations in the X-linked histone H3K27me3 demethylase ubiquitously transcribed X...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Van der Meulen, Joni, Sanghvi, Viraj, Mavrakis, Konstantinos, Durinck, Kaat, Fang, Fang, Matthijssens, Filip, Rondou, Pieter, Rosen, Monica, Pieters, Tim, Vandenberghe, Peter, Delabesse, Eric, Lammens, Tim, De Moerloose, Barbara, Menten, Björn, Van Roy, Nadine, Verhasselt, Bruno, Poppe, Bruce, Benoit, Yves, Taghon, Tom, Melnick, Ari M., Speleman, Frank, Wendel, Hans-Guido, Van Vlierberghe, Pieter
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2015
Konular:
Plenary Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347284/
https://ncbi.nlm.nih.gov/pubmed/25320243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-577270
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