The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive form of leukemia that is mainly diagnosed in children and shows a skewed gender distribution toward males. In this study, we report somatic loss-of-function mutations in the X-linked histone H3K27me3 demethylase ubiquitously transcribed X...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Blood
Päätekijät: Van der Meulen, Joni, Sanghvi, Viraj, Mavrakis, Konstantinos, Durinck, Kaat, Fang, Fang, Matthijssens, Filip, Rondou, Pieter, Rosen, Monica, Pieters, Tim, Vandenberghe, Peter, Delabesse, Eric, Lammens, Tim, De Moerloose, Barbara, Menten, Björn, Van Roy, Nadine, Verhasselt, Bruno, Poppe, Bruce, Benoit, Yves, Taghon, Tom, Melnick, Ari M., Speleman, Frank, Wendel, Hans-Guido, Van Vlierberghe, Pieter
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2015
Aiheet:
Plenary Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347284/
https://ncbi.nlm.nih.gov/pubmed/25320243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-577270
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