Discovery of Akt Kinase Inhibitors through Structure-Based Virtual Screening and Their Evaluation as Potential Anticancer Agents

Akt acts as a pivotal regulator in the PI3K/Akt signaling pathway and represents a potential drug target for cancer therapy. To search for new inhibitors of Akt kinase, we performed a structure-based virtual screening using the DOCK 4.0 program and the X-ray crystal structure of human Akt kinase. Fr...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Chuang, Chih-Hung, Cheng, Ta-Chun, Leu, Yu-Ling, Chuang, Kuo-Hsiang, Tzou, Shey-Cherng, Chen, Chien-Shu
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346889/
https://ncbi.nlm.nih.gov/pubmed/25648320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms16023202
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