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Reciprocal interactions between mitral valve endothelial and interstitial cells reduce endothelial-to-mesenchymal transition and myofibroblastic activation

Thickening of mitral leaflets, endothelial-to-mesenchymal transition (EndMT), and activated myofibroblast-like interstitial cells have been observed in ischemic mitral valve regurgitation. We set out to determine if interactions between mitral valve endothelial cells (VEC) and interstitial cells (VI...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Shapero, Kayle, Wylie-Sears, Jill, Levine, Robert A., Mayer, John E., Bischoff, Joyce
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346432/
https://ncbi.nlm.nih.gov/pubmed/25633835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.01.006
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