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Probing myo-inositol 1-phosphate synthase with multisubstrate adducts
The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to...
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| Опубликовано в: : | Org Biomol Chem |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4346228/ https://ncbi.nlm.nih.gov/pubmed/23132282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2ob26577j |
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