Tumor evolution and intratumor heterogeneity of an epithelial ovarian cancer investigated using next-generation sequencing

BACKGROUND: The extent to which metastatic tumors further evolve by accumulating additional mutations is unclear and has yet to be addressed extensively using next-generation sequencing of high-grade serous ovarian cancer. METHODS: Eleven spatially separated tumor samples from the primary tumor and...

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Gepubliceerd in:BMC Cancer
Hoofdauteurs: Lee, Jung-Yun, Yoon, Jung-Ki, Kim, Boyun, Kim, Soochi, Kim, Min A, Lim, Hyeonseob, Bang, Duhee, Song, Yong-Sang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346117/
https://ncbi.nlm.nih.gov/pubmed/25881093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1077-4
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