Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice

Tafenoquine (TQ), a new synthetic analog of primaquine, has relatively poor bioavailability and associated toxicity in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. A microemulsion formulation of TQ (MTQ) with sizes <20 nm improved the solubility of TQ and enhanced the oral bioa...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Melariri, Paula, Kalombo, Lonji, Nkuna, Patric, Dube, Admire, Hayeshi, Rose, Ogutu, Benhards, Gibhard, Liezl, deKock, Carmen, Smith, Peter, Wiesner, Lubbe, Swai, Hulda
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346002/
https://ncbi.nlm.nih.gov/pubmed/25759576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S76317
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