Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome

Tetrahydrobiopterin is a cofactor synthesized from GTP with well-known roles in enzymatic nitric oxide synthesis and aromatic amino acid hydroxylation. It is used to treat mild forms of phenylketonuria. Less is known about the role of tetrahydrobiopterin in lipid metabolism, although it is essential...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Watschinger, Katrin, Keller, Markus A., McNeill, Eileen, Alam, Mohammad T., Lai, Steven, Sailer, Sabrina, Rauch, Veronika, Patel, Jyoti, Hermetter, Albin, Golderer, Georg, Geley, Stephan, Werner-Felmayer, Gabriele, Plumb, Robert S., Astarita, Giuseppe, Ralser, Markus, Channon, Keith M., Werner, Ernst R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345615/
https://ncbi.nlm.nih.gov/pubmed/25675482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414887112
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