Metabolic Engineering of an ATP-Neutral Embden-Meyerhof-Parnas Pathway in Corynebacterium glutamicum: Growth Restoration by an Adaptive Point Mutation in NADH Dehydrogenase

Corynebacterium glutamicum uses the Embden-Meyerhof-Parnas pathway of glycolysis and gains 2 mol of ATP per mol of glucose by substrate-level phosphorylation (SLP). To engineer glycolysis without net ATP formation by SLP, endogenous phosphorylating NAD-dependent glyceraldehyde-3-phosphate dehydrogen...

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Bibliographic Details
Published in:Appl Environ Microbiol
Main Authors: Komati Reddy, Gajendar, Lindner, Steffen N., Wendisch, Volker F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345364/
https://ncbi.nlm.nih.gov/pubmed/25576602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.03116-14
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