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Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations

BACKGROUND: DNA polymerase ε (Pol ε) is essential for S-phase replication, DNA damage repair and checkpoint control in yeast. A pol2-Y831A mutation leading to a tyrosine to alanine change in the Pol ε active site does not cause growth defects and confers a mutator phenotype that is normally subtle b...

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Bibliografiske detaljer
Main Authors: Pavlov, Youri I, Maki, Satoko, Maki, Hisaji, Kunkel, Thomas A
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC434536/
https://ncbi.nlm.nih.gov/pubmed/15163346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-2-11
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